By S. Eva Singletary, Geoffrey L. Robb
Edited via remarkable leaders within the box of breast ailment (Dr. Singletary chairs the Breast melanoma Committee for the yank collage of Surgeons), this ebook bargains first-hand suggestion on prevention, analysis, remedy and reconstruction by means of well-known gurus. The paintings gains the private therapy protocols of the head physicians and surgeons focusing on breast ailment. stipulations lined comprise benign and malignant tumors, endocrine and anxious problems, and adolescent and grownup difficulties in either men and women. Key good points: - comprises authoritative recommendation in accordance with the medical event of famous investigators - offers a fantastic assessment of breast affliction, beginning with breast screening, and advancing to subject matters reminiscent of silicone autoimmune disorder and breast reconstruction innovations - Takes a well-rounded method of sufferer therapy, with articles on psychosocial difficulties on the topic of breast melanoma, and the follow-up care of the breast melanoma sufferer - followed through a CD-ROM with the whole textual content and illustrations of the e-book, in absolutely searchable PDF records viewers: scholars and practitioners in surgical procedure, plastic and reconstructive surgical procedure, oncology, and gynecology.
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Additional resources for Advance Therapy of Breast Disease
Experimental data showed suppression of 90% of incident rat mammary tumors with the continuous administration of tamoxifen therapy, although the tumors did reappear when tamoxifen was d i s ~ o n t i n u e d This . ~ ~ ~latter observation raised the still unanswered question concerning whether tamoxifen prevents new primary breast cancers or delays (ie, suppresses) their appearance. Although rat mammary tumors do occur after the cessation of tamoxifen therapy, the chemoprotective effect of tamoxifen in the adjuvant treatment trials appears to extend beyond the time of drug cessation.
Bignell GR, Barfoot R, Seal S, et al. Low frequency of somatic mutations in the LKB-Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res 1998;58:1384-6. 17. Claus EB, Risch N, Thompson WD. Genetic analysis of breast cancer in the Cancer and Steroid Hormone study. Am J Hum Genet 1991;48:232-42. 18. Statement of the American Society of Clinical Oncology: genetic testing for cancer susceptibility. J C h Oncol 1996;14:1730-6. 19. Couch FJ, Farid LM, Deshano ML, et al. BRCA-2 germline mutations in male breast cancer cases and breast cancer families.
Several hereditary syndromes featuring breast cancer have been recognized, and specific genes identified. These include the hereditary breast and breast/ovarian cancer syndrome (HBOC) associated with the BRCA-1 and BRCA-2 genes, Li-Fraumeni syndrome with the TP53 gene, Cowden syndrome with the PTEN gene and Muir-Torre syndrome, a variant of hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome), associated with a number of mismatch repair genes. Other genes remain to be discovered, since these known genes appear to account for no more than 30 to 70 percent of families in which breast cancer clustering is strongly suggestive of a hereditary predisposition.