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Download A Multidisciplinary Approach to Myelin Diseases II by K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.) PDF

By K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)

The illnesses that fall lower than the generalized team of demyelinating illnesses -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the point of interest of globally situation. This quantity comprises papers offered via best scientists who attended the NATO complex examine Workshop held on the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This booklet is an replace of the former one released in 1987 of the learn mentioned at the same assembly held in 1986. It was once determined to carry this 2d assembly due to the fact there was nice growth within the advances in knowing the myelinogenesis technique within the final 5 years. The workshop amassed jointly scientists from many fields equivalent to mobile and molecular biology, immunology, pathology, virology and naturally medical neurology. Stimulating rules have been exchanged within the wish that extra wisdom of demyelinating ailments can result in new theraupetic ways. even supposing the workshop was once more often than not just like the former one, this time there has been extra emphasis on experimental types and medical elements. within the former using animal and mobile versions as instruments for realizing the pathological mechanisms associated with human illness have been mentioned; within the latter the clinicians defined the filtering down of easy study to scientific remedy The booklet of this interdisciplinary alternate is to make recognized the result of the newest study one of the investigators from allover the area curious about those studies.

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This was confirmed by assaying the 6-galactosidase activity in an highly enriched oligodendrocyte population purified from the MBP-lacZ animals. These data demonstrated that the 256bp proximal region of the MBP gene promoter is sufficient to confere oligodendroglial specific transcription. Although the transgene construct contains, in addition to the 256bp sequence upstream from the MBP major transcription site, the 90 first bp from exon I b, in situ hybridization experiments with a lacZ cRNA probe showed that the transgene RNA was strictly located at the oligodendrocyte cell bodies, suggesting that the 5' region of exon lb of the MBP gene is not responsible for the migration of the MBP transcripts.

We also wish to thank Dr. Rainer Kuhn 34 (Ciba-Geigy) for kindly providing the retrQvirus vector pSLX-CMV and Dr. Dieter Brockmann (University of Essen) for the cell lines Psi2 and NIH3T3. This work was supported by the BMFf and the EThyssen Stiftung. , 1985, A very strong enhancer located upstream of an immediate early gene human cytomegalovirus. Cell 41:521-530. , Wilms, S. , 1993, Differential expression of two PMP22(CD25ISRI3) transcripts in vivo and in vitro, EMBO J. submitted. , 1979, Studies on cultured rat cells.

1988). In contrast, underexpression of PMP22 mRNA has only little effect on Schwann cell proliferation, suggesting that PMP22 may not be required to maintain cell division but to induce growth arrest. The mechanism by which PMP22 exerts its function is unknown and remains rather obscure with respect to the pathology of the dysmyelinating neuropathy CMTIA. , 1992), Schwann cell proliferation is abnormally high, in contrast to what we would have predicted from our present investigation. However, since the level of PMP22 mRNA and the protein expression in CMTIA has not yet been determined it is still unclear whether the PMP22 expression level is elevated or perhaps even reduced.

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